BCL2 Gene Research List
2011 Research
→Expression of Inflammatory Cytokines, BCL2 and Cathepsin D are Altered in Lymphoblasts of Autistic Subjects
- Focused on the possible role of inflammation and apoptosis in autism
- Included a study group consisting of individuals with autism and a control group with neurotypical individuals
- Researched levels of cytokines, cathepsin D protease, and expression of BCL2 in lymphoblasts
2010 Research
→BDNF-Akt-Bcl2 Antiapoptotic Signaling Pathway is Compromised in the Brain of Autistic Subjects
- Focused on determining if the mechanisms regulating apoptosis in the autistic brain are deregulated
- Researched levels of BCL2 protein (expressed by the BCL2 gene)
- Also focused on pathways that regulate BCL2 gene expression
→Global Methylation Profiling of Lymphoblastoid Cell Lines Reveals Epigenetic Contributions to Autism Spectrum Disorders and a Novel Autism Candidate Gene, RORA, Whose Protein Product is Reduced in Autistic Brain
- Focused on the relationship of DNA methylation to autism spectrum disorders
- Report on methylation status of BCL2 gene
- Also discusses levels of BCL2 expressed in the brain of individuals with autism compared to controls
→Cathepsin D and Apoptosis Related Proteins Are Elevated in the Brain of Autistic Subjects
- Primarily focuses on the association of cathepsin D with autism
- Also discusses the relationship of BCL2 expression to autism
- Report on findings of BCL2 expression in the brains of individuals with autism compared to controls in this study and a previous study
2001 Research
→Altered Levels of BCL2 and p53 Proteins in Parietal Cortex Reflect Deranged Apoptotic Regulation in Autism
- No research summary available
Additional Resources:
- More Info on Genes Associated with Autism
- More Information on the Genetics of Autism
- More Information About Autism
