Autism and the Environment: Tylenol (Acetaminophen, Paracetamol)

Autism Environmental Risk Factors: Tylenol (Acetaminophen, Paracetamol)

2012 Research

Acetaminophen May Mediate Oxidative Stress and Neurotoxicity in Autism

  • No research abstract available

2010 Research

Can Autism Be Triggered by Acetaminophen Activation of the Endocannabinoid System?

  • Provides background on research suggesting a link between autism and Tylenol (acetaminophen) use
  • Discusses how the mechanism of action of acetaminophen affects the cannabinoid system
  • Hypothesizes that acetaminophen use may activate the cannabinoid system resulting in the alteration of normal brain development

Similarities in Features of Autism and Asthma and a Possible Link to Acetaminophen Use

  • Discusses relationship of genes often associated with autism to inflammation and innate immunity pathways
  • Describes how asthma is also related to these inflammation and innate immunity pathways
  • Discusses how acetaminophen may increase the risk of developing asthma and autism

2009 Research

Did Acetaminophen Provoke the Autism Epidemic?

  • A review article
  • Discusses previous research suggesting that autism may be caused by acetaminophen use
  • Describes how acetaminophen use may be associated with autism
  • Contains section that asks questions arguing against the acetaminophen/autism hypothesis

A Response to the Article on the Association Between Paracetamol/Acetaminophen: Use and Autism by Stephen T. Schultz

  • No summary available

2008 Research

Acetaminophen (Paracetamol) Use, Measles-Mumps-Rubella Vaccination, and Autistic Disorder: the Results of a Parent Survey

  • A case-control study
  • Included 163 children (83 with an autism spectrum disorder and 80 neurotypical children)
  • Studied the possible association of autism with acetaminophen and ibuprofen use after receiving the MMR vaccine

2003 Research

Is Fever Suppression Involved in the Etiology of Autism and Neurodevelopmental Disorders?

  • A hypothesis paper
  • Discusses the use of acetaminophen (paracetamol) by pregnant mothers to treat fevers during pregnancy
  • Hypothesizes that acetaminophen use during pregnancy may alter normal brain development
  • Provides suggestions for testing the hypothesis and the implications of confirming the hypothesis


Additional Resources:

Research List for Tylenol (Acetaminophen, Paracetamol) as a Cause of Autism


  1. Ann Bauer says

    More studies recent studies supporting a paracetamol association to autism:
    Prenatal and perinatal analgesic exposure and autism: an ecological link.

    Evidence that Increased Acetaminophen use in Genetically Vulnerable Children Appears to be a Major Cause of the Epidemics of Autism, Attention Deficit with Hyperactivity, and Asthma

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