Autism Treatments: Aripiprazole: In the Treatment of Irritability Associated with Autistic Disorder in Pediatric Patients

Research for Aripiprazole Autism Treatment:

Side Effects and Efficay of Abilify (Aripiprazole) in Treating Irritability in Autistic Children Researched
Study Researches Efficacy of Abilify (Aripiprazole) in Treating Irritability Associated with Autism

Irritability is a symptom often associated with autism.  Abilify (aripiprazole) is one of several medications that have been studied to treat irritability in individuals with autism.  Further research was conducted to determine the efficacy of Abilify in treating irritability.  The research also focused on side effects associated with its use.  The findings were published in an article titled Aripiprazole: in the Treatment of Irritability Associated with Autistic Disorder in Pediatric Patients.

The study consisted of 3 separate phases.  The first 2 phases lasted 8 weeks while the 3rd phase lasted 52 weeks.  The study was a randomized, double-blind, placebo-controlled trial.  The participants included children with autism from the ages of 6 to 17.  The dose of Abilify (aripiprazole) ranged from 2 mg to 15 mg per day in the two 8-week trials.

The researchers reported significant improvements in irritability as measured by the Aberrant Behavior Checklist Irritability and Clinical Global Impression-Improvement scales with Abilify treatment compared to placebo.  They also reported that treatment with aripiprazole resulted in mild to moderate side effects and was well-tolerated my most participants.  The study indicated that weight gain associated with the use of aripiprazole occurred during the first 3 to 6 months of treatment.


Curran, Monique P. “Aripiprazole: in the treatment of irritability associated with autistic disorder in pediatric patients.” Paediatric Drugs 13.3 (2011) : 197-204. Print.


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